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About Thalassemia:

What is Thalassemia?

Thalassemia (thal-a-SE-me-ahs) is “inherited blood disorder”. "Inherited" means disorder is transferred to children from parents through genes.
Thalassemia causes to the body to create fewer healthy red blood cells (RBC) and less hemoglobin standard. Hemoglobin is an iron-rich protein in red blood cells. It transmits oxygen to all the parts of the body. Hemoglobin also transmits co2 from the body to the lungs, wherever it is breathing out.

Who having thalassemias can have kind or severe anemia. Anemia is caused by lower than standard number of red blood cells or not-enough hemoglobin in the red blood cells.


Usual hemoglobin, also called hemoglobin A, has 4 protein chains and 2 beta globin and 2 alpha globin. The two major types of thalassemia, alpha and beta, are named after deficiency in these protein chains.

4 genes (2 from each parent) are needed to make enough alpha globin protein chains. Alpha thalassemia attribute occurs when 1 or 2 of the 4 genes are missing. When more than 2 genes are missing, may be anemia occurs.
The majority severe shape of alpha thalassemia is called alpha thalassemia main or hydrops fetal. Babies who have this type of disorder generally die before or shortly after birth.

2 genes (1 from each parent) are needed to create enough beta globin protein chains. Thalassemia beta arise while one gene or both genes are altered.
Severity of beta thalassemia depends upon how much 1 or both genes are affected. When both genes are affected, the finish result is modest to severe anemia. The severe anemia form of beta thalassemia is called as main thalassemia or Cooley's anemia.

Thalassemias have an effect on males and females. The disorders transpire mainly often among people of Greek, Italian, Southern Asian, Middle Eastern, and African descent. Severe shapes generally are diagnosed in early on childhood and are lifelong conditions.


Hemoglobin is made of two proteins 1.Alpha globin and 2.beta globin. Thalassemia arises if there is a error in a gene that assists organize production of one of these proteins.

There are 2 types of thalassemia:

Alpha thalassemia occurs when a gene or genes connected to the alpha globin protein are absent or changed (mutated).

Beta thalassemia occurs while similar gene defects have an effect on making of the beta globin protein.

Alpha thalassemias occurs mostly persons from China, Southeast Asia, the Middle East, and African descent.

Beta thalassemias transpire mainly persons of Mediterranean origin. A smaller area of other Asians, African Americans and Chinese can be affected.

There are a lot of types of thalassemia. Each type has lots of different subtypes.

Both alpha thalassemia and beta thalassemia include the following two forms:

Thalassemia major

Thalassemia minor

You should inherit the gene deficiency from both parents to build up thalassemia major.

Thalassemia minor occurs if you receive the defective gene from only one parent. Persons with this form of the disorder can hauler of the disease. The bulk of time, these people does not have symptoms.

Beta Thalassemia mainly is also called as “Cooley's anemia”.

Risk factors for thalassemia includes:

Asian, Chinese, Mediterranean, or African American ethnicity
Family history of the disorder.




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